Effectiveness of oil-based nanoemulsions with molecular docking of its antimicrobial potential

The biological properties of plant oils are improved by their conversion to nanoemulsions (NEs). This study evaluated the antimicrobial, antioxidant, and anti-hemolytic efficacy coconut salad rocket NEs. result gas chromatography-mass spectroscopy analysis showed varied constituents such as palmitic acid, trimethylsilyl ester; 2,3-bis(acetyloxy)propyl laurate in oil, 2-lauro-1,3-didecoin, n-butyl laurate; laurin, tri-; laurin oil. NEs diameter was 24.6 29.2 nm, respectively. More inhibitory activity compared with non-NEs form against Bacillus cereus, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Candida albicans, Aspergillus flavus detected. Coconut oil its caused 14.3% (anti-hemolysis 85.7%) 22% hemolysis 78%), Salad 3.4% 20.9%, respectively at 1000 µg/mL. Antioxidant reflected more IC50 (39.3 109.4 µg/mL) than (35.8 80.5 µg/mL), Molecular docking ester 2-lauro-1,3-didecoin S. aureus (PDB=7BGE) C. albicans protein (PDB=3DRA) revealed optimal binding mode that had most energy interaction sites.